Senior Scientist, Downstream Process Development (Contract) - AW
@ Adverum Biotechnologies, Inc.Senior Scientist, Downstream Process Development (Contract) - AW
This job is still taking applications, but it's been up a while.
About the job
Adverum Biotechnologies, owned by Eli Lilly, develops gene therapies for ocular diseases. The role involves developing and optimizing AAV downstream processes for clinical and commercial use, with a focus on scalability, GMP compliance, and cross-functional collaboration.
Requirements
- 6+ years in downstream process development
- Experience with AAV or viral vectors
- Expertise in chromatography and filtration
- Knowledge of GMP and regulatory guidelines
- Strong problem-solving skills
Qualifications
- Ph.D
- in relevant field or M.S
- with experience
- Experience in late-stage gene therapy development
- Ability to troubleshoot complex bioprocesses
Full job description
Adverum Biotechnologies, Inc., wholly owned subsidiary of Eli Lilly and Company, is a mission-driven clinical-stage company that aims to establish gene therapy as a new standard of care for highly prevalent ocular diseases with the aspiration of developing functional cures to restore vision and prevent blindness. Leveraging the research capabilities of its proprietary intravitreal (IVT) platform, Adverum is developing durable, single-administration therapies designed to be delivered in physicians’ offices to eliminate the need for frequent ocular injections to treat these diseases. By overcoming the challenges associated with current treatment paradigms for these debilitating ocular diseases, Adverum aspires to transform the standard of care, preserve vision, and create a profound societal impact around the globe.
Note to Recruiters and Agencies
All recruiter and agency inquiries must go through Adverum’s internal Talent Acquisition team. Unsolicited resumes sent to Adverum will be considered Adverum's property. Adverum’s Talent Acquisition team must expressly engage agencies for any requisition. Direct contact with hiring managers by agencies will not be tolerated and may affect your ability to work with Adverum in the future.
Adverum is looking for a Senior Scientist, Downstream Process Development to join the Process Development team at our Redwood City, CA office. The individual will be part of the team responsible for developing and optimizing the downstream process development activities for adeno-associated virus (AAV) gene therapy programs. The successful candidate will participate in late-stage activities including design and optimization of the process as needed using historical batch data and manufacturing needs; process characterization; and tech-transfer of downstream processes to support clinical and commercial manufacturing. This role requires a deep understanding of chromatography, filtration, and gene therapy-specific challenges in AAV vector production, as well as experience in transitioning processes to GMP-compliant manufacturing. This position is onsite 5 days a week.
What You’ll Do:
About You:
- Ph.D. in Biochemistry, Chemical Engineering, Molecular Biology, or related field with 4-6+ years of relevant experience in downstream process development; or M.S. with 8+ years of experience.
- Proven experience in AAV or other viral vector production, preferably in late-stage development for clinical/commercial scale manufacturing.
- Strong expertise and in-depth knowledge in functioning and troubleshooting of purification process development/manufacturing equipment such as chromatography and filtration systems.
- Experience with scalable, AKTA, depth filtration, and TFF systems.
- Knowledge of GMP requirements and regulatory guidelines for gene therapy products.
- Prefer to have knowledge of DOE principles, process characterization, and BLA enabling activities.
- Background in authoring sections of regulatory submissions, including IND, or BLA filings.
- Excellent problem-solving skills with the ability to troubleshoot and optimize complex bioprocesses.
- Strong communication and leadership skills to manage cross-functional projects and mentor team members.
Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.
At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self. We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation
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