Research Associate I/II, Preclinical Research (Contract)

@ Lexeo Therapeutics
Lexeo Therapeuticslexeotherapeutics.com

Research Associate I/II, Preclinical Research (Contract)

New York, NY
Posted 1 day ago

About the job

Lexeo Therapeutics is a clinical-stage biotech company focused on genetic diseases, especially cardiovascular and neurological. This role supports iPSC-CM platform research, assay development, and data generation, offering opportunities to contribute to cutting-edge drug discovery and gain valuable biotech experience.

Requirements

  • Bachelor’s degree in relevant field
  • 1-3 years lab experience
  • Culturing iPSC cardiomyocytes
  • Experience with cellular transfection
  • Knowledge of PCR, Western blotting

Qualifications

  • Strong lab skills
  • Attention to detail
  • Ability to work onsite in NYC
  • Effective communicator
  • Fast-paced environment adaptation

Full job description

Role Summary


The Research Associate I/II will support Lexeo’s human induced pluripotent stem cell–derived cardiomyocyte (iPSC-CM) platform, a core in vitro system used to evaluate target engagement, mechanism of action, and potency across discovery and preclinical programs. This hands-on laboratory role will execute established cellular and molecular assays, contribute to assay development, and generate high-quality data. The position reports to the Head of Cardiac Research and receives day-to-day scientific direction from the Preclinical Scientist leading the platform. This is an exciting opportunity to join a cutting-edge drug discovery team advancing new therapies for patients with genetic heart disease while gaining valuable experiences for a future career in biotech and medicine



Primary Responsibilities

  • Generate and validate cellular knockdown and overexpression models
  • Culture and maintain human iPSC-derived cardiomyocytes and other mammalian cell lines using aseptic technique
  • Perform ddPCR, qPCR, conventional PCR, gel electrophoresis, Western blotting, and ELISA to support mechanism-of-action and target-validation studies
  • Maintain complete and accurate laboratory records and contribute to the development and revision of assay SOPs
  • Analyze experimental data and prepare concise summaries for Preclinical team


    • Required Skills and Qualifications

  • Bachelor’s degree in cell biology, molecular biology, pharmacology, or a related field with 1-3 years of industry and/or academic lab experience
  • Hands-on experience culturing iPSC and differentiation protocols for cardiomyocytes/neurons
  • Hands-on experience with cellular transfection methods
  • Experience with several of the following methods: ddPCR, qPCR, semi-quantitative PCR, Western blotting, ELISA, flow cytometry, and fluorescence microscopy
  • Strong laboratory skills, rigorous record-keeping, attention to detail, and the ability to work effectively in a fast-paced environment
  • Ability to work onsite 5 days/week at our New York City HQ



    • Preferred Skills and Qualifications

  • Prior experience in an in vitro pharmacology group within the biotechnology or pharmaceutical industry
  • Experience with high-throughput screening platforms, automation and workflows
  • Experience with the Jess automated Western blotting platform
  • Experience with TR-FRET, NanoBiT, FLIPR, or MEA assays
  • Familiarity with engineered heart tissue models and cardiac biology
  • Familiarity with AI-native, agentic lab-in-the-loop workflows connecting experimental design, automated execution, real-time data analysis, and iterative decision-making
  • Demonstrated ability to generate, document, and communicate high-quality experimental results; publications or patents are a plus



    • About LEXEO


    Lexeo Therapeutics is a New York City-based, clinical stage company dedicated to reshaping the path of genetic disease. By advancing pioneering science, Lexeo seeks to set a new standard in the treatment of cardiovascular and neurological genetic diseases, charting the path to patient outcomes once thought out of reach. The Company is advancing a portfolio of therapeutic candidates designed to address the underlying genetic causes of disease, including LX2006 for Friedreich ataxia (FA), LX2020 for plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.

    LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.



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